Jobs

We are inviting suitably qualified candidates for the following positions:

Post-doctoral Fellow Position, Institute of Medical Biology (IMB), Singapore
Postdoctoral research fellow, National University of Singapore
Postdoctoral positions available to investigate Sox2 in embryonic and neural stem cells
Postdoc in Molecular Biology at University Konstanz

Post-doctoral Fellow Position, Institute of Medical Biology (IMB), Singapore

The Gene Expression in Differentiation group, lead by Dr Takahiro Edwin Nakano, is looking to recruit a post-doctoral fellow to investigate human embryonic stem (hES) cell differentiation. The position is immediately available. We are interested in visualizing events such as early differentiation, neural induction, and lineage-specific neural/glial differentiation from hES cells. To this end, we currently focus on 1) the identification of novel cell type-specific enhancers using transgenic mouse or zebrafish, and 2) the visualization of differentiation from human ES reporter lines by using the identified enhancers.

We are looking for a highly skilled and motivated postdoctoral research fellow.

Qualifications:
•   Experience in Stem Cell Biology.
•   Experience in hES cell culture is highly desirable.
•   Strong background and knowledge in Molecular Biology.
•   Experience in transgenic zebrafish or FACS analysis is an advantage.
•   In-depth knowledge in a broad range of developmental biology.
• Able to demonstrate creativity, technical independence and excellent communication skills.
•   Good interpersonal skills and will be required to train and assist other members of the team.

Please send your application including cover letter, CV, publication list, and names of three references to Takahiro Nakano DVM, PhD (takahiro.nakano@imb.a-star.edu.sg).

Only short listed candidates will be notified.

For further information and application please contact:
Takahiro Nakano
Institute of Medical Biology
8A Biomedical Grove, #06-06, Immunos
Singapore 138648
Tel: 65-6407-0166
Email: takahiro.nakano@imb.a-star.edu.sg
Website: http://www.imb.a-star.edu.sg/Default.aspx?tabid=150

Postdoctoral research fellow, National University of Singapore

A postdoctoral research fellow position is immediately available at the Bioimaging Lab, Division of Bioengineering, National University of Singapore. The successful applicant will join a collaborative research team including scientists from the National University of Singapore, the Institute of Medical Biology, and the Bioinformatics Institutes of A*STAR. He/she will be trained in a multidisciplinary environment and mainly involved in development of novel microscopy methods for understanding basic problems of stem cell biology.

Qualifications:
The ideal candidate should have a Ph. D. degree in optical science/engineering, biomedical engineering, electrical engineering, or related fields, and the capability to work and communicate with other team members. Experience with light microscopy and cellular imaging is desirable. Some knowledge about signal acquisition and processing is a plus. Application will be considered until the position is filled. Candidates are encouraged to apply as early as possible.

Contact:
Dr. Nanguang Chen

Division of Bioengineering & ECE Department
National University of Singapore
7 Engineering Dr. 1, #E3A-04-15,
Singapore 117576
DID: 65-6516-4401
Fax: 65-6872-3069
Email: biecng@nus.edu.sg
Website: http://www.bioeng.nus.edu.sg/people/chenng/

Postdoctoral positions available to investigate Sox2 in embryonic and neural stem cells

Two post-doctoral positions are available to work on the application of advanced fluorescent microscopy techniques (F-techniques) to investigate embryonic and neural stem cells.

The positions are funded by an SSCC-SBIC grant.

Stem cell growth and differentiation are fundamental processes that need to be understood for the optimal use of these cells in regenerative medicine. For the growth of embryonic (ESCs) and neural stem cells (NSCs) the transcription factor Sox2 plays a crucial role. In ESCs Sox2 and Oct4 act synergistically to maintain self-renewal and pluripotentcy. In this study, we aim to follow temporally and spatially the activity of Sox2 complexes. This knowledge would provide us with greater potential for specific lineage and tissue generation, alongside greater understanding of mammalian development and potential treatments of developmental abnormalities and neurodegenerative disease. In this project we aim to use a combination of the F-techniques; FRET (Forster Resonance Energy Transfer), FLIM (Fluorescence Lifetime Imaging Microscopy) and FCCS (Fluorescence cross correlation spectroscopy) and 3-D imaging to evaluate the localisation and activity Sox2 protein complexes in ESCs and NSCs.

For further information and application please contact:
Sohail Ahmed,
Institute of Medical Biology,
8A Biomedical Grove, #06-06, Immunos,
Singapore 138648.
Tel: 65-6407-0165
Email: sohail.ahmed@imb.a-star.edu.sg
Website: http://www.imb.a-star.edu.sg/Default.aspx?tabid=90

POSTED: March 17 2008.

Postdoc in Molecular Biology at University Konstanz

A postdoc position is available immediately for three years for a highly motivated and enthusiastic, English-speaking scientist with a strong background in molecular cell biology. Experience with lentiviral vectors and mammalian reporter and silencing systems would be of strong advantage.

The future work areas of the candidate involve genetic modification of murine and human embryonic stem cells for improved neurotoxicity assays, and the genetic modification of cells to elucidate mechanisms of neurotoxicity and neurodegenerative disease (Alzheimer’s and Parkinson’s.).

The position will be at the Doerenkamp-Zbinden chair at the University of Konstanz (http://www.uni-konstanz.de/FuF/Bio/research/Arbeitsgruppen/Leist/Homepage/index.html).

This unit has been recently set-up, and offers top equipment for cell culture, microscopy, and high content screening, as well as excellent sub-groups working on neural differentiation of murine and embryonic human stem cells and on cellular neurodegeneration models.

The laboratory communication language is English, and the group members have good social interactions. The University of Konstanz is one of the German “Excellence” universities and located in a pleasant area of southern Germany, at the Lake of Konstanz, next to the Swiss Alps. Applications, including contact information of two referees, should be submitted to Brigitte.Schanze@uni-konstanz.de.